Is tramadol contraindicated in seizures?

Tramadol should not be administered to patients receiving SSRIs, TCAs and antipsychotics. In all patients with a first seizure, especially in young adults, the history of tramadol abuse should be taken upon. It is advisable that tramadol should not be used in epileptic patients.

What can lower the seizure threshold?

What people with epilepsy are not sufficiently informed about are the factors which lower the seizure threshold and make them more liable to have seizures. Such factors include stress, sleep deprivation, alcohol, menstruation and, especially in children, intercurrent infection and fever.

Which drugs are known to decrease the seizure threshold and should be avoided in patients with epilepsy?

Medications that lower seizure threshold include the antidepressant and nicotinic antagonist bupropion, the atypical opioid analgesics tramadol and tapentadol, reserpine, theophylline, antibiotics (fluoroquinolones, imipenem, penicillins, cephalosporins, metronidazole, isoniazid) and volatile anesthetics.

What does reduction of seizure threshold mean?

A high seizure threshold means that a seizure is less likely to occur, while a low seizure threshold means that a seizure is more likely to occur. Antiepileptic drugs (AEDs) attempt to raise the seizure threshold, whereas other medications may lower the seizure threshold.

Why would tramadol cause seizures?

It stimulates opioid receptors, and inhibits noradrenaline and serotonin reuptake. Seizures and serotonin syndrome are amongst the more commonly reported serious adverse reactions attributed to tramadol in the CARM and the WHO International Drug Monitoring databases.

Which medication should be avoided in a patient with a history of seizures?

Pseudoephedrine – a decongestant that shrinks blood vessels in the nasal passages. This is the active ingredient in medications like Sudafed and any medications with “D” on the end (Zyrtec D, Claritin D or Mucinex D). Bupropion – also known as Wellbutrin, which is used for smoking cessation and as an anti-depressant.

What drugs raise seizure threshold?

Category	Examples
Analgesics	Opioids (eg, meperidine, tramadol)
Anticancer drugs¶	Busulfan Chlorambucil Cytarabine Doxorubicin Etoposide Fluorouracil Interferon alfa Methotrexate Mitoxantrone Nelarabine Platinum-based drugs (eg, cisplatin) Vinblastine Vincristine

Can tramadol cause epilepsy?

Seizures are a rare side effect of tramadol. Tramadol-related seizures are short, tonic-clonic seizures that, like other drug-related seizures, are self-limiting. This epileptogenic effect of tramadol occurs at both low and high doses.

Does dehydration lower seizure threshold?

Keep your fluids topped up all the time. Dehydration can make it more likely for you to have a seizure. This is particularly important when you are exercising.

Why does tramadol cause seizures?

Can chlorpromazine cause seizures?

Among the first generation antipsychotics, chlorpromazine appears to be the one most associated with the greatest risk of seizures, whereas in the newer antipsychotics clozapine is thought to be the most likely to cause seizures of that group of medications.

What kind of seizures does tramadol cause?

Does tramadol lower seizure threshold?

Tramadol, a powerful narcotic pain reliever, can lower the seizure threshold, reports the medical reference website Epilepsy.com. The likelihood of seizures associated with tramadol use increases in patients concurrently taking antidepressants, antipsychotic medications and other narcotics.

Does Zoloft lower seizure threshold?

Sertraline is a selective serotonin reuptake inhibitor that may decrease seizure threshold, ie, making one more susceptible to seizures.

What medications reduce seizures?

For partial seizures, common first-line medications include carbamazepine (Tegretol), phenytoin (Dilantin), Oxcarbazepine (Trileptal) and, especially in children, ethosuximide (Zarontin). Additionally, phenobarbital is often the medication of choice for seizures in very young children. What are common seizure medication side effects?

Does tramadol cause increased risk of bleeding?

Like other narcotics used to treat pain, patients taking tramadol may abuse the drug and become addicted to it. Tramadol is not a nonsteroidal anti-inflammatory drug (NSAID), therefore, it does not have the increased risk of stomach ulcers and internal bleeding that can occur with NSAIDs.