What drug class is Fenoldopam?

Fenoldopam mesylate (Corlopam) is a drug and synthetic benzazepine derivative which acts as a selective D1 receptor partial agonist. Fenoldopam is used as an antihypertensive agent….Fenoldopam.

When do you use Fenoldopam?

Fenoldopam is indicated for in-hospital, short-term (up to 48 hours) management of severe hypertension when rapid, but quickly reversible, emergency reduction of blood pressure is clinically indicated, including malignant hypertension with deteriorating end-organ function.

How does Fenoldopam work in the body?

Fenoldopam is a selective dopamine agonist that causes systemic and renal vasodilation by stimulating dopamine D1 receptors. Fenoldopam is administered intravenously and has a rapid onset of action (5 minutes) and a short duration of action (30 to 60 minutes).

Is Fenoldopam a vasodilator?

Fenoldopam is a vasodilator, a dopamine (D1) receptor agonist that increases cardiac output, heart rate, and renal sodium excretion and preserves glomerular filtration rate. Its antihypertensive effect is comparable to that of nitroprusside, but is slower in onset. The dose can be titrated every 15 minutes.

Is Fenoldopam used in hypertensive emergency?

Conclusions: Fenoldopam safely and effectively lowers blood pressure in a dose-dependent manner in patients with hypertensive emergencies. Observations supporting potential risk factors for hypertensive emergency are discussed.

What are the contraindications of Fenoldopam?

Contraindications / Precautions

• Asthma, sulfite hypersensitivity. Certain formulations of fenoldopam contain sodium metabisulfite.
• Glaucoma, increased intraocular pressure.
• Geriatric.
• Pregnancy.
• Breast-feeding.

Does Fenoldopam release nitric oxide?

Fenoldopam, a dopaminergic DA1 agonist, induces vasodilatation via nitric oxide (NO), and this may be associated with mesenteric arterial injury.

What is corlopam used for?

Corlopam(Intravenous) Fenoldopam is used to quickly lower blood pressure for a short period of time. This medicine is usually given in an emergency situation, until you can be given other medicines to control your blood pressure. Fenoldopam may also be used for purposes not listed in this medication guide.

Is Fenoldopam an alpha agonist?

Fenoldopam is an agonist at D1-like dopamine receptors, binds to α2-adrenoceptors, increasing renal blood flow. Fenoldopam is a rapid-acting vasodilator. It is an agonist for D1-like dopamine receptors and binds with moderate affinity to α2-adrenoceptors.

What is the most common cause of malignant hypertension?

In many people, high blood pressure is the main cause of malignant hypertension….They include:

• Collagen vascular disease, such as scleroderma.
• Kidney disease.
• Spinal cord injuries.
• Tumor of the adrenal gland.
• Use of certain medications, including birth control pills and MAOIs.
• Use of illegal drugs, such as cocaine.

How do you know if you have malignant hypertension?

Symptoms of malignant hypertension include: Blurred vision. Change in mental status, such as anxiety, confusion, decreased alertness, decreased ability to concentrate, fatigue, restlessness, sleepiness, or stupor. Chest pain (feeling of crushing or pressure)

Is malignant hypertension curable?

The prognosis of patients with malignant hypertension is guarded. Five-year survivals of 75\% to 84\% have been reported with treatment; without treatment, the life expectancy is less than 24 months. Most deaths are a result of heart failure, stroke, or renal failure.

What is Fenoldopam used to treat?

Fenoldopam is used to quickly lower blood pressure for a short period of time. fenoldopam is usually given in an emergency situation, until you can be given other medicines to control your blood pressure. Fenoldopam may also be used for purposes not listed in this medication guide.

What is fillfenoldopam used for?

Fenoldopam is only found in individuals that have used or taken this drug. It is a dopamine D1 receptor agonist that is used as an antihypertensive agent. It lowers blood pressure through arteriolar vasodilation. [PubChem]Fenoldopam is a rapid-acting vasodilator.

What receptors does fenoldopam bind to?

Fenoldopam, a dopamine (DA) receptor agonist, binds specifically to peripheral DA1 receptors and to alpha-2 adrenoceptors with moderate affinity. However, this agent exhibits no significant affinity to DA2, other alpha adrenergic, beta adrenergic, muscarinic, or serotonergic receptors.

What is the mechanism of action of finasteride (Fenoldopam)?

Fenoldopam is a rapid-acting vasodilator. It is an agonist for D1-like dopamine receptors and binds with moderate affinity to α2-adrenoceptors. It has no significant affinity for D2-like receptors, α1 and β adrenoceptors, 5HT1 and 5HT2 receptors, or muscarinic receptors.