What is a C3 function?

The C3 gene provides instructions for making a protein called complement component 3 (or C3). This protein plays a key role in a part of the body’s immune response known as the complement system.

What is C3 GN?

C3 glomerulonephritis (C3GN) is a recently described entity that shows a glomerulonephritis on light microscopy (LM), bright C3 staining and the absence of C1q, C4 and immunoglobulins (Ig) on immunofluorescence microscopy (IF), and mesangial and/or subendothelial electron dense deposits on electron microscopy (EM).

Is C3 glomerulonephritis hereditary?

C3G is a complex genetic disorder that is rarely inherited in a simple mendelian fashion. In most persons with C3G, inheritance is complex and incompletely understood. For these reasons, recurrence risk to family members is not known but likely very low.

What is C3 in kidney biopsy?

C3G stands for complement 3 glomerulopathy. The “C3” refers to a blood protein that plays a key role in normal immunity and in the development of this disease. More on this later. The “G” is for glomerulopathy, meaning damage to the glomeruli in the kidney.

What is a glomerular disease?

Glomerular diseases affect the filtering units of your kidney, the glomeruli. Symptoms include foamy urine, pink urine, high blood pressure and swelling in your face, hands, ankles or feet. Many diseases can cause glomerular disease. The leading cause is diabetic nephropathy.

What is C3 disease?

Complement 3 glomerulopathy (C3G) is a rare kidney disease that has two forms: dense deposit disease (DDD) and C3 glomerulonephritis (C3GN). Each is caused by genetic or acquired problems in controlling the body’s complement system, which helps fight infections. Genetic problems can be inherited or not inherited.

Is C3 low in IgA nephropathy?

In several studies in Asia, a high serum IgA:C3 ratio was associated with disease progression. Another study showed that a decreased serum C3 level (<90 mg/dl) predicted a worse outcome, which was defined by a higher rate of doubling of serum creatinine and progression to ESRD.

What is IgA disease?

IgA nephropathy (nuh-FROP-uh-thee), also known as Berger’s disease, is a kidney disease that occurs when an antibody called immunoglobulin A (IgA) builds up in your kidneys. This results in local inflammation that, over time, can hamper your kidneys’ ability to filter waste from your blood.

What is normal GFR for age?

In adults, the normal eGFR number is more than 90. eGFR declines with age, even in people without kidney disease. See chart below for average estimated eGFR based on age….What is a normal eGFR number?

What is the normal GFR?

A GFR of 60 or higher is in the normal range. A GFR below 60 may mean kidney disease. A GFR of 15 or lower may mean kidney failure.

What does a low C3 blood test mean?

If only your C3 complement level is low and all other complement components are normal, it’s usually because of an inherited component deficiency. This makes it more likely that you will develop certain autoimmune disorders. More often, you will have low levels of several complement components at once.

What does a low C3 and C4 mean?

Low C3 and C4 levels, below 60 for C3 and 15 for C4 (in the usual American measure), occur in active lupus, especially in the setting of kidney disease or immune breakdown of blood cells (autoimmune hemolytic anemia, AIHA). Some types of lupus, such as brain disease, do not cause low complement levels.