What is chemical name of clopidogrel?
Table of Contents
What is chemical name of clopidogrel?
Clopidogrel bisulfate
Clopidogrel bisulfate
| PubChem CID | 115366 |
|---|---|
| Molecular Formula | C16H18ClNO6S2 |
| Synonyms | Clopidogrel bisulfate 120202-66-6 CLOPIDOGREL SULFATE Plavix Iscover More… |
| Molecular Weight | 419.9 |
| Parent Compound | CID 60606 (Clopidogrel) |
What is clopidogrel made from?
Each tablet contains hydrogenated castor oil, hydroxypropyl cellulose, mannitol, microcrystalline cellulose and polyethylene glycol 6000 as inactive ingredients. The pink film coating contains ferric oxide, hypromellose 2910, lactose monohydrate, titanium dioxide and triacetin.
What is clopidogrel classification?
Clopidogrel is in a class of medications called antiplatelet medications. It works by preventing platelets (a type of blood cell) from collecting and forming clots that may cause a heart attack or stroke.
What is the difference between Plavix and clopidogrel?
Plavix and Brilinta are both brand-name drugs. A generic form of Plavix, called clopidogrel, is available for use. However, a generic form of Brilinta is not yet available. A generic drug is an exact copy of a brand-name medication.
What is the chemical structure of clopidogrel?
Clopidogrel is a thienopyridine that is 4,5,6,7-tetrahydrothieno[3,2-c]pyridine in which the hydrogen attached to the nitrogen is replaced by an o-chlorobenzyl group, the methylene hydrogen of which is replaced by a methoxycarbonyl group (the S enantiomer).
Where is clopidogrel metabolized?
liver
In the liver, clopidogrel is oxidized into 2-oxo-clopidogrel by CYP1A2, CYP2B6, and CYP2C19. This is then converted into clopidogrel’s active metabolite by CYP2B6, CYP2C9, CYP2C19, and CYP3A4. CYP2C19 is of particular importance as it has a major contribution to both of these metabolic steps.
Why is clopidogrel a prodrug?
Clopidogrel (Plavix) is a prodrug that is metabolized by cytochrome P450 in the liver to an active metabolite that specifically and irreversibly blocks the platelet ADP P2Y12 receptor (as discussed in detail in Chapter 62).
Where is clopidogrel absorbed?
Clopidogrel is a prodrug that is absorbed in the intestine [3,4] and activated in the liver [5]. The conversion of clopidogrel to its active metabolite requires two sequential oxidative steps.
Which is safer aspirin or clopidogrel?
The CAPRIE trial reported that patients treated with clopidogrel had lower risk of composite vascular events (ischemic stroke, AMI, or death) than aspirin (5.32\% vs 5.83\%), with a relative risk reduction (RRR) of 8.7\% in favor of clopidogrel (95\% CI = 0.3–16.5, p 0.043).
What is the major side effect of clopidogrel?
Easy bleeding/bruising, stomach upset/pain, diarrhea, and constipation may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects.
How is clopidogrel metabolized?
Metabolism of clopidogrel Clopidogrel is a prodrug that requires metabolic activation in two steps (Figure 1). The majority of the clopidogrel dose (>85\%) is metabolized to inactive clopidogrel-carboxylic acid by human carboxylesterase 1 (CES1) [Tang et al. 2006].
Where is clopidogrel metabolised?
Owing to its extensive metabolism, clopidogrel is not detected in human plasma. Clopidogrel is a prodrug that is absorbed in the intestine [3,4] and activated in the liver [5]. The conversion of clopidogrel to its active metabolite requires two sequential oxidative steps.
The structure of clopidogrel (aka Methyl (2S)- 2- (2-chlorophenyl)-2- (6,7-dihydrothieno [3,2-c]pyridin-5 (4H)-yl)acetate) is shown below: The chemical properties of this compound can be predicted from the functional groups present. There is a methyl ester which will be subject to hydrolysis.
What is the mechanism of action of clopidogrel bisulfate?
Clopidogrel Bisulfate is a thienopyridine with antiplatelet activity. Clopidogrel bisulfate irreversibly alters the platelet receptor for adenosine diphosphate ( ADP ), thereby blocking the binding of ADP to its receptor, inhibiting ADP -mediated activation of the glycoprotein complex GPIIb/IIIa,…
What are the side effects of clopidogrel and aspirin?
Adverse effects occurring in at least 2\% of patients receiving clopidogrel and aspirin in the CURE /Clopidogrel in Unstable Angina to Prevent Recurrent Ischemic Events/ study included chest pain, headache, dizziness, abdominal pain, dyspepsia, or diarrhea.
What is the absorption rate of clopidogrel?
After single and repeated oral doses of 75 mg per day, clopidogrel is rapidly absorbed. Absorption is at least 50\%, based on urinary excretion of clopidogrel metabolites.